Übersicht
colloquia - [ 10.12.2007 (11.00) ]
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"Rational Design for Crop Protection "
Sprecher: Dr. Klaus-Jürgen Schleifer, BASF Ludwigshafen
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Abstract (by author)
The plethora of new experimental techniques, like combinatorial chemistry or robot controlled high-throughput screening, has significantly increased the capacity of biochemical assays for the search of new active ingredients. But unfortunately, they did not deliver the anticipated high quality output but just dramatically increased the number of data points and the costs of the discovery process. Therefore computer-assisted virtual techniques were established to reduce the infinite chemical space to a finite number of potentially active compounds. The presentation will introduce BASF’s crop protection research in general, and focuses on the integrated computational chemistry support. Furthermore, identification of a natural product and the following optimization cycles will be demonstrated yielding finally to a successful market product.
Dr. Schleifer studied pharmacy at the Freie Universität Berlin. In 1992
he finished his doctoral thesis with the focus on medicinal chemistry
of antithrombotic nitrososydnonimines. Then he joined to the
theoretical group of Prof. Höltje to investigate voltage-gated ion
channel modulation applying different molecular modelling and
bioinformatics techniques. After his “Habilitation” in 1999, he was
appointed as associate professor (C2) at the Heinrich-Heine-Universität
Düsseldorf. In 2001 he changed from academia to industry and succeeded
Prof. Kubinyi as head of the computational chemistry activities at BASF
Ludwigshafen. Since that time he cares responsibility for life sciences
modelling, X-ray crystallography of proteins and small molecules,
bioinformatics, several bioanalytical labs and the polymorphism
activities at the competence center for specialty chemicals of BASF.
Furthermore he is lecturer for Drug Design at the University of
Düsseldorf.
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Ort:
Carl-Bosch-Auditorium des Studios der Villa Bosch, 69118 Heidelberg, Schloss-Wolfsbrunnenweg 33 (Eingang Studio - ca. 100 m vom Eingang zur Villa Bosch entfernt, auf der Talseite des Schloss-Wolfsbrunnenweges; Näheres zur Anfahrt siehe unter www.studio.villa-bosch.de.
Parken:
Tiefgarage „Unter der Boschwiese“ (unentgeltlich).
Contact:
Bärbel Mack
EML Research gGmbH
Schloss-Wolfsbrunnenweg 33
69118 Heidelberg
Phone: +49 (0)6221 - 533 - 201
Fax: +49 (0)6221 - 533 - 298
Email: [email protected]
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