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WORK INFORMATION
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BIOGRAPHICAL INFORMATION
Rebecca Wade started to work at the EML in 2001.
She studied at the University of Oxford (B.A. Hons. in physics, 1985; D. Phil. in Molecular Biophysics, 1988).
She then did postdoctoral research in Houston and Illinois, primarily in biomolecular
simulation, before taking up a position as a group leader in the Structural
and Computational Biology Programme at the European Molecular Biology Laboratory
(EMBL) in Heidelberg in 1992. She continues to lead the
"Molecular
modelling, simulation and design" group at EMBL.
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RESEARCH INTERESTS
In the Molecular and Cellular Modeling group, our main focus is on proteins and finding out how
they interact with their molecular binding partners and function. We develop and apply computational
approaches to address questions such as: How do proteins recognize and distinguish their binding partners?
How tightly and quickly do they bind? By what mechanisms do they bind?
Can binding partners and binding modes be predicted? Our studies are mostly based on
the three-dimensional structures of macromolecules. We aim to make
concerted use of bioinformatics and physical simulation approaches in order to develop
methods for understanding how biomolecules work and aiding the rational design of therapeutic agents.
Techniques cover a wide spectrum from interactive, web-based visualization tools to
complex molecular and Brownian dynamics simulations. Applications range from in-depth simulation studies of
particular proteins to large-scale computational analysis of protein families and of whole genomes.
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PROFESSIONAL ACTIVITIES
- Editor: Journal of Molecular Recognition.
- Editorial Board: Journal of Computer-Aided Molecular Design, Journal of Modeling and Molecular Graphics, Biopolymers
- Member of Faculty of 1000: Theory and Simulation Section
- Member: American Chemical Society, Biophysical Society, American Association for the Advancement of Science,
Iota Sigma Pi - National Honor Society for Women in Chemistry, Molecular Graphics and Modelling Society, QSAR and Modelling Society
- Recent/upcoming meetings organized
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PERSONAL INTERESTS
Too many to list......
Druckansicht
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