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Research Staff - Dr. Rebecca Wade
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| WORK INFORMATION
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BIOGRAPHICAL INFORMATION
Rebecca
Wade started to work at the EML in 2001. She studied at the University
of Oxford (B.A. Hons. in physics, 1985; D. Phil. in Molecular
Biophysics, 1988). She then did postdoctoral research at the universities of Houston and
Illinois, primarily in biomolecular simulation, before taking up a
position as a group leader in the Structural and Computational Biology
Programme at the European Molecular Biology Laboratory (EMBL) in Heidelberg in 1992. She was Adjunct Professor at the International University in Germany in Bruchsal from 2001-2003.
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RESEARCH INTERESTS
In
the Molecular and Cellular Modeling group, our main focus is on
proteins and finding out how they interact with their molecular binding
partners and function. We develop and apply computational approaches to
address questions such as: How do proteins recognize and distinguish
their binding partners? How tightly and quickly do they bind? By what
mechanisms do they bind? Can binding partners and binding modes be
predicted? Our studies are mostly based on the three-dimensional
structures of macromolecules. We aim to make concerted use of
bioinformatics and physical simulation approaches in order to develop
methods for understanding how biomolecules work and aiding the rational
design of therapeutic agents. Techniques cover a wide spectrum from
interactive, web-based visualization tools to complex molecular and
Brownian dynamics simulations. Applications range from in-depth
simulation studies of particular proteins to large-scale computational
analysis of protein families and of whole genomes.
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PROFESSIONAL ACTIVITIES
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PERSONAL INTERESTS
Too many to list......
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